Coronary venous retroinfusion of deferoxamine, an oxygen free radical scavenger, reduces infarct size
نویسندگان
چکیده
منابع مشابه
Oxygen-based free radical generation by ferrous ions and deferoxamine.
Deferoxamine accelerates the autooxidation of iron as measured by the rapid disappearance of Fe2+, the associated appearance of Fe3+, and the uptake of oxygen. Protons are released in the reaction. The formation of H2O2 was detected by the horseradish peroxidase-catalyzed oxidation of scopoletin, and the formation of hydroxyl radicals (OH.) was suggested by the formation of the OH. spin trap ad...
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BACKGROUND Although free radicals have been reported to play a role in the expansion of ischemic brain lesions, the effect of free radical scavengers is still under debate. In this study, the temporal profile of ischemic stroke lesion sizes was assessed for more than one year to evaluate the effect of edaravone which might reduce ischemic damage. METHODS We sequentially enrolled acute ischemi...
متن کاملMyocardial infarct size-limiting effect of ischemic preconditioning was not attenuated by oxygen free-radical scavengers in the rabbit.
BACKGROUND The limiting effect of ischemic preconditioning on infarct size has been reported in canine hearts, which contain considerable amounts of xanthine oxidase, a free radical-producing enzyme. Furthermore, a recent study suggested that free radicals generated during preconditioning may contribute to the cardioprotective effect of preconditioning. The present study examined 1) whether pre...
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The β1-adrenergic-receptor (ADRB1) antagonist metoprolol reduces infarct size in acute myocardial infarction (AMI) patients. The prevailing view has been that metoprolol acts mainly on cardiomyocytes. Here, we demonstrate that metoprolol reduces reperfusion injury by targeting the haematopoietic compartment. Metoprolol inhibits neutrophil migration in an ADRB1-dependent manner. Metoprolol acts ...
متن کاملFree radical scavenger, edaravone, reduces the brain ischemic damage especially in the white matter
Background Although inflammation and free radicals have been reported to play deteriorative role in the ischemic brain lesion, the effect of free radical scavenger in ischemic stroke patients is still under debate. For exploring the hypothesis that the ischemic damage is reduced by edaravone or not, we evaluated the temporal profile of the size of ischemic stroke lesion assessed by MRI for more...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1991
ISSN: 0735-1097
DOI: 10.1016/0735-1097(91)92204-y